Objective:When to add human milk fortification is not uniformed at home and abroad.This Meta-analysis evaluated the effects of early and late human milk fortification on the growth and complications of premature infants.Methods:We searched Cochrane Library,Embase,PubMed,Web of Science,VIP,Wanfang Data,CBM,CNKI for randomized controlled trials about early versus delayed human milk fortification in premature infants.The retrieval time was from the establishment of each database to June 2023.Two researchers extracted data and assessed their quality,then used RevMan 5.3 for analysis.Results:We included 8 studies about 812 premature infants.The results of Meta-analysis showed that compared with the late fortification group,the early group of body weight growth rate[mean difference[(MD)=1.73 g·(kg·d)-1,95% CI(0.94,2.52)g·(kg·d)-1,P＜0.05]extrauterine growth restriction[RR =0.80,95% CI(0.69,0.93),P＜0.05]were statistically significant in the early fortification group.There were no significant difference in body length growth rate,head circumference growth rate,incidence rate of necrotizing enterocolitis,incidence of feeding intolerance,nosocomial infection,parenteral nutrition,hospital stay,days to regain birth weight between the two groups.Conclusion:According to the current evidence,early human milk fortification may be beneficial to the body weight growth of premature infants and reduce the probability of extrauterine growth restriction,but has little or no effect on body length growth rate,head circumference growth rate,incidence rate of necrotizing enterocolitis,incidence of feeding intolerance,nosocomial infection,parenteral nutrition,hospital stay,recovery to birth weight.
human milk fortificationadd timepremature infantgrowthcomplicationMeta-analysis
NETL
NSTL
万方数据
