Objective:To evaluate the expression level,prognostic value and potential mechanisms of leucine-rich repeat-containing protein 59(LRRC59)in cervical cancer.Methods:GEPIA database was used to examine the expression level of LRRC59 mRNA in 13 normal cervical tissues and 306 cervical cancer tissues.Real-time quantitative polymerase chain reaction was conducted to detect the expression of LRRC59 mRNA in 10 normal cervical tissues and 12 cervical cancer tissues.Kaplan-Meier Plotter database was used to analyze the relationship between LRRC59 expression and overall survival and relapse-free survival of cervical cancer patients.ROC curve was plotted and univariate and multivariate Cox regression analysis were performed using the transcriptome and clinical data from TCGA database.Gene set enrichment analysis was used to explore the mechanisms of LRRC59 in cervical cancer.Results:The expression of LRRC59 mRNA was increased in cervical cancer tissues compared with normal cervical tissues(P＜0.05).The patients with high expression of LRRC59 had a shorter overall survival(P =0.022)and relapse-free survival(P＜0.001).LRRC59 had a certain diagnostic value in the prognosis of cervical cancer patients(AUC at 3 years was 0.610,AUC at 5 years was 0.633).The high expression of LRRC59 was an independent risk factor predicting poor prognosis in cervical cancer patients[HR =2.645,95% CI(1.378～5.078),P = 0.003].LRRC59 regulated the development of cervical cancer through multiple tumor-associated signaling pathways.Conclusion:The expression of LRRC59 mRNA is increased in cervical cancer tissues,and the high expression of LRRC59 is associated with poor prognosis in cervical cancer patients.LRRC59 may be a novel therapeutic target for cervical cancer.
leucine-rich repeat-containing protein 59cervical cancerbioinformatics analysisprognosismechanism
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