Objective:To analyze the clinical features of 6 patients with primary aldosteronism(PA),the results of adrenal venous sampling(AVS),and the application value of two PA subtyping predictive scoring systems in order to improve the understanding,diagnosis and treatment of the disease among clinicians.Methods:The general clinical data,diagnosis and treatment of 6 patients diagnosed with PA and underwent AVS in Nanjing Lishui People's Hospital from March 2022 to April 2023 were retrospectively analyzed,and the application value of SPACE and CLR scoring systems were evaluated combined with published papers.Results:All the 6 patients with an average age of 50 years presented with hypertension,and 4 of the 6 with hypokalemia.The upright plasma aldosterone-to-renin ratio(ARR)in all patients exceeded the usual cut-off point,the confirmatory tests were positive,and the success rate of bilateral AVS was 50% .Along with 10 cases published in China in the past 5 years,the SPACE scoring system displayed a positive/negative predictive value of 100% /50% ,avoiding AVS in 41.6% of patients.The agreement rate of CLR and SPACE scoring system in predicting PA subtyping was 75% .Conclusion:For patients with PA,if AVS is unavailable or of unilateral success,the SPACE or CLR scoring systems can be integrated in clinical practice to enable some patients to be properly treated in the cases of avoiding initial or repetitive AVS.
primary aldosteronismadrenal venous samplingsubtypingscoring system
NETL
NSTL
万方数据
