Meta-analysis of the effect of subcooling combined with minimally invasive intracranial hematoma removal on neurological function in patients with hypertensive intracerebral hemorrhage
Objective:The purpose of this study was to evaluate the clinical efficacy of subcooling combined with minimally invasive hematoma removal on the protection of neurological function in patients with hypertensive intracerebral hemorrhage through Meta-analysis.Methods:Computer searches was conducted in multiple databases including PubMed,Embase,Cochrane Central Register of Controlled Trials,Web of Science,China Knowledge Network(CNKI),China Biomedical Literature Database(CBM),Wanfang Database(WANFANG),and China Science and Technology Periodical databases(VIP).Based on the established database of hypertensive intracerebral hemorrhage patients treated with subcooling therapy after minimally invasive hematoma removal,the literatures related to its randomized controlled trials(RCTs)were screened and assessed for quality.Meta-analysis was performed with the Revman 5.3 software.Results:There were a total of 12 papers included in this study,all of which were single-center RCT studies that involved 1 093 patients.Compared to the conventional treatment group(control group),patients with hypertensive intracerebral hemorrhage after minimally invasive hematoma removal combined with subcooling therapy(hereinafter referred to as the combined treatment group),9 papers showed that the combined treatment had a significant impact on decreasing the National Institute of Health stroke scale(NIHSS)scores(MD =-4.29,95%CI-5.27--3.23,P＜0.001);3 papers showed that the combined treatment could effectively improve the Fugl-Meyer assessment scale(FMA)scores(MD = 27.66,95%CI 18.45-36.86,P<0.001);3 papers showed that the combined treatment was effective in improving the Glasgow coma scale(GCS)scores(MD =34.79,95%CI 33.19-36.39,P<0.001);and 8 papers showed that the combined treatment was effective in improving the Barthel Index(BI)(MD =8.72,95%CI 6.89-10.54,P<0.001);all of the included literature showed that the combination therapy could enhance the efficiency(RR =1.28,95%CI 1.20-1.36,P<0.001);while 5 papers showed that the combination therapy did not have any significant reduction in the incidence of adverse effects(MD =0.52,95%CI 0.32-0.85).Conclusion:The combination of subcooling and minimally invasive hematoma removal has the effect of promoting the recovery of neurological function in patients with hypertensive intracerebral hemorrhage.
维普
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