Analysis of influencing factors of nosocomial infection in children with acute leukemia undergoing chemotherapy and study on prevention and control strategies
Objective:To explore the influencing factors of nosocomial infection in children with acute leukemia(AL)undergoing chemotherapy,and to analyze the prevention and control strategies.Methods:A total of 155 children with AL undergoing chemotherapy admitted to the hospital from March 2020 to March 2022 were selected,and the nosocomial infection and other related clinical data during hospitalization were retrospectively analyzed.Univariate and multivariate Logistic regression analysis were used to explore the influencing factors of nosocomial infection in children with AL undergoing chemotherapy.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of independent influencing factors and combined predictors of multivariate Logistic on nosocomial infection in children.The predictive value of combined predictors was tested by cross validation.Results:The incidence of nosocomial infection in 155 children with AL undergoing chemotherapy was 30.97%.Multivariate Logistic regression analysis showed that chemotherapy stage as induction remission stage,skin and mucosal damage,and long hospitalization time were independent risk factors for nosocomial infection in children.High neutrophil count and albumin level were independent protective factors for nosocomial infection in children(P＜0.05).ROC curve analysis showed that each independent influencing factor(chemotherapy stage as induction remission stage,skin and mucosal damage,long hospitalization time,high neutrophil count,high albumin level)had certain predictive efficacy for nosocomial infection in children,and area under curve(AUC)were 0.638,0.710,0.813,0.785,0.716 respectively.The prediction AUC of the combined predictor was 0.928,the standard error was 0.022,95%CI 0.884-0.971,and the Yoden index was 0.729,P<0.001.The cross validation test showed that the classification accuracy of joint predictors was 88.39%.Conclusion:The influencing factors of nosocomial infection in children with AL undergoing chemotherapy include chemotherapy stage as induction remission stage,skin and mucosal damage,long hospitalization time,high neutrophil count and albumin level,and the combination of the above factors has a good predictive effect on nosocomial infection in children,which could provide guidance for the formulation of prevention and control countermeasures.
维普
万方数据
