Objective:To investigate the correlation between hot flushes and coronary heart disease in menopausal women.Methods:A total of 218 menopausal female patients aged 40-60 who were admitted to the Department of Cardiology,Zhongda Hospital,Southeast University from June 2020 to March 2021 and underwent coronary angiography(CAG)were enrolled.According to the CAG results,patients were divided into coronary heart disease group(106 cases)and control group(112 cases).The severity of menopausal symptoms was assessed with the modified Kupperman menopausal score.Coronary lesion severity was evaluated by Gensini score.Results:The mean modified Kupperman score in the coronary heart disease group was significantly higher than that in control group,and the incidence of hot flushes was also higher than that in the control group,among which the differences were statistically significant(all P<0.001).There were significant differences in frequency and duration of hot flushes between the coronary heart disease group and the control group(P<0.05).Multivariate Logistic regression analysis showed that the modified Kupperman score was positively correlated with the proportion of coronary heart disease diagnosed(OR=1.12,95%CI 1.07-1.17).The proportion of patients with 3-9 times and≥10 times hot flushes per day diagnosed with coronary heart disease was 4.60 and 6.03 times that of patients without hot flashes,the proportion of patients with hot flashes lasting 1-3 years and>3 years who were diagnosed with coronary heart disease was 4.43 and 7.55 times that of patients without hot flashes,all of which were statistically significant(all P<0.05).Linear regression analysis showed that in the coronary heart disease group,the Gensini score of patients with hot flashes was 11.17 points higher than that of asymptomatic patients(95%CI 2.74-19.60).Conclusion:Hot flushes,frequent and persistent hot flushes in menopausal women are correlated with the occurrence and severity of coronary heart diease.
维普
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