Objective:To investigate the reverse effect of SGLT-2i on left ventricular hypertrophy(LVH)in patients with hypertension and diabetes.Methods:This study included 204 LVH patients with hypertension and type 2 diabetes who were hospitalized in Zhongda Hospital affiliated to Southeast University in Nanjing,Jiangsu Province from January 2018 to December 2022.According to whether they used SGLT-2i or not,they were divided into SGLT-2i group and control group,with 102 cases in each group.We collected baseline and follow-up data from all enrolled patients,including age,gender,body mass index(BMI),blood pressure,creatinine,fasting blood glucose,glycated hemoglobin,medication use,and left ventricular structural indicators[left ventricular mass index(LVMI),left ventricular mass(LVM),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVDd),interventricular septal thickness(IVST),and left ventricular posterior wall thickness(LVPWT)].The baseline and follow-up related indicators were compared between the two groups.Results:The analysis of baseline data found that there were statistically significant differences in age,glycosylated hemoglobin,and IVST between groups(P＜0.05).Compared with baseline,there were statistically significant differences in LVMI,LVM,LVDd,LVPWT,diastolic blood pressure,and fasting blood glucose before and after treatment in the control group(P＜0.05).There were statistically significant differences in LVMI,LVM,LVDd,IVST,LVPWT,fasting blood glucose,and creatinine before and after treatment in the SGLT-2i group(P＜0.05).After using 1∶1 propensity score to match the balanced confounding factors,the comparison between the SGLT-2i group and the control group showed that there were statistically significant differences in LVMI and LVM between the groups(P＜0.05),while the differences in other indicators were not statistically significant(P＞0.05).A multivariable linear regression model showed that SGLT-2i treatment was associated with the decreased LVMI and LVM(LVMI:β=-0.303,P=0.002;LVM:β=-0.303,P=0.002).However,SGLT-2i had no effect on LVEF(P＞0.05).Conclusion:SGLT-2i can reverse LVH in hypertensive patients with diabetes.
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