Objective:To evaluate the clinical efficacy of arthroscopic debridement combined with platelet-rich plasma(PRP)injection in the treatment of knee osteoarthritis(KOA).Methods:Randomized controlled trial(RCT)of arthroscopic debridement combined PRP injection in the treatment of knee osteoarthritis were searched and selected from databases including China Biology Medicine(CBM),China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP database,PubMed,Embase and Cochrane Library.With a time frame from library construction to August 2023.RevMan 5.3 and Stata 14 were used to perform Meta-analysis.Results:A total of 2 064 papers were retrieved,and 17 papers were finally included in the Meta-analysis after screening,and involving 1 280 participants.The results of the analysis showed that:(1)Compared with arthroscopic debridement alone,arthroscopic debridement combined with PRP injection had a higher clinical efficacy rate(OR=5.37,95%CI 3.21-8.99,P＜0.001).(2)Arthroscopic debridement combined with PRP injection in the treatment of KOA was superior to arthroscopic debridement alone with regard to VAS score(March:MD=-1.50,95%CI-2.04--0.96,P＜0.001;June:MD=-1.33,95%CI-1.77--0.89,P＜0.001;Dec:MD=-1.30,95%CI-1.98--0.62),P=0.000 2);Lysholm score(March:MD=10.26,95%CI 5.49-15.04,P＜0.001;June:MD=4.95,95%CI 0.59-9.31,P=0.03;Dec:MD=9.76,95%CI 7.89-11.63,P＜0.001],as well as TNF-α level(MD=-22.55,95%CI-41.70--3.40,P=0.02)and IL-1β level(MD=-24.38,95%CI-30.85--17.90,P＜0.001].(3)The incidence of adverse effects of arthroscopic debridement combined with PRP injection therapy was not statistically significant compared to arthroscopic debridement alone.Conclusion:Compared with arthroscopic debridement alone,arthroscopic debridement combined with PRP injection in the treatment of KOA has better clinical efficacy in terms of increased clinical efficacy,reduced joint pain,improved joint function,and reduced levels of inflammatory factors,but more high-quality RCTs are needed for further validation.
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