不同干预措施对ICU获得性衰弱患者应用效果的网状Meta分析
Effects of different interventions on intensive care unit-acquired weakness:a network Meta-analysis
程敏 1刘芹 1甘皓月 1刘航呈 1何梅2
作者信息
- 1. 川北医学院 护理学院,四川 南充 637000;绵阳市中心医院/电子科技大学医学院附属绵阳医院 护理部,四川 绵阳 621000
- 2. 绵阳市中心医院/电子科技大学医学院附属绵阳医院 护理部,四川 绵阳 621000
- 折叠
摘要
目的:利用网状Meta分析评价不同干预措施对ICU获得性衰弱的应用效果.方法:计算机检索Embase、PubMed、Web of Science、万方数据知识服务平台、中国知网(CNKI)、维普网(VIP)数据库,搜集相关的随机对照试验(RCT),检索时间从建库至2023 年5 月.由2 名研究者独立筛选文献和提取资料,评价纳入研究的偏倚风险后,采用Stata 15.1 软件进行网状Meta分析.结果:共纳入 29 篇RCT,包括2 188 例患者.网状Meta分析结果显示:MRC评分最佳概率排序中效果最优的是中药治疗+针灸治疗.APACHEⅡ评分最佳概率排序中效果最优的是中药治疗+针灸治疗.MBI评分最佳概率排序中效果最优的是康复训练+体外膈肌起搏.ICU住院时间最佳概率排序中效果最优的是早期康复训练.机械通气时间最佳概率排序中效果最优的是中药治疗+针灸治疗.总住院时间最佳概率排序中效果最优的是早期康复训练.IL-6 最佳概率排序中效果最优的是早期康复训练.结论:当前证据表明,12 种干预措施对ICU获得性衰弱患者均有所帮助,其中,中药治疗+针灸治疗、早期康复训练、康复训练+体外膈肌起搏可能是较为有效的干预方式,未来还需要更多的研究进行论证.
Abstract
Objective:To evaluate the effect of different interventions on intensive care unit-acquired weakness by mesh Meta-analysis.Methods:Embase,PubMed,Web of Science,WanFang Data,CNKI and VIP databases were systematically searched from inception to May 2023.The reviewers independently selected studies,extracted data and evaluated the quality of studies.Stata 15.1 Software was used to perform the Meta-analysis.Results:A total of 29 articles were included,including 2 188 patients.The results of network Meta-analysis showed that in the best probability ranking of MRC score the best effect was Chinese medicine treatment+acupuncture treatment.In the best probability ranking of APACHE Ⅱ score,the best effect was traditional Chinese medicine treatment+acupuncture treatment.In the best probability ranking of MBI score,the best effect was rehabilitation training+external diaphragm pacing.In the best probability ranking of ICU stay,the best effect was early rehabilitation training.In the best probability ranking of mechanical ventilation time,the best effect was traditional Chinese medicine treatment+acupuncture treatment.In the best probability ranking of total hospital stay,early rehabilitation training had the best effect.The best probability ranking of IL-6 was early rehabilitation training.Conclusion:The current evidence showed that the 12 interventions are helpful for intensive care unit-acquired weakness,but Chinese medicine therapy+acupuncture therapy,early rehabilitation training,rehabilitation training+in vitro diaphragm pacing may be the best intervention,and more studies are needed to prove it in the future.
关键词
重症监护病房/获得性衰弱患者/临床疗效/网状Meta分析/随机对照试验Key words
intensive care unit/patients with acquired weakness/clinical effect/network Meta-analysis/randomized controlled trial引用本文复制引用
出版年
2024
NETL
NSTL
万方数据