Objective:To explore the causal association between plasma vascular endothelial growth factor(VEGF)family proteins and placenta praevia using a two-sample Mendelian randomization(MR)analysis.Methods:Genome-wide association study(GWAS)data of plasma VEGF family proteins were obtained from the UK Biobank and IEU database,and the GWAS data of placenta praevia were obtained from the FinnGen database.The instrument variables were screened out according to the set threshold.Two-sample MR analysis was performed using inverse-variance weighted(IVW),MR-Egger,weighted median,and weighted mode method,with IVW as the primary analysis method.Cochran's Q test was employed for testing heterogeneity of the results.MR-Egger regression and MR-PRESSO method were conducted to assess horizontal pleiotropy of the results.The leave-one-out method was employed to verify the sensitivity of the results.Results:Plasma VEGFA was causally associated with an increased risk of placenta praevia(P＜0.05,OR＞1),while plasma VEGFB,VEGFC,VEGFD and placental growth factor(PLGF)were not causally associated with the risk of placenta praevia.Cochran's Q test showed that there was no heterogeneity in the results of the MR analysis.MR-Egger regression and MR-PRESSO method showed that there was no horizontal pleiotropy in the results of the MR analysis.Leave-one-out method demonstrated that no single instrumental variable strongly influenced the MR results.Conclusion:The present study indicates a causal association between plasma VEGFA and placenta praevia,suggesting that detecting plasma VEGFA may have clinical significance for predicting placenta praevia.
NETL
NSTL
万方数据
