Objective:To investigate the causal relationship between the plasma lipidome and bipolar disorder(BD).Methods:We obtained the genome-wide association study(GWAS)data for 179 plasma lipidomes and BD from publicly available summary statistical databases and set single-nucleotide polymorphisms(SNPs)related to the plasma lipidomes as instrumental variables for an initial two-sample Mendelian randomization(MR)analysis.We conducted replication analysis and mate-analysis on the lipidomes that meet the selection criteria in the preliminary MR analysis to further explore the robustness of the causal association between lipidome and BD.Results:The preliminary MR analysis showed a causal association between 13 kinds of plasma lipidomes and BD,which disappeared after FDR correction.However,the mate analysis results showed that phosphatidylcholine(16:0_18:1)(OR=1.123,P=0.001),phosphatidylcholine(16:0_18:3)(OR=1.087,P=0.001),phosphatidylcholine(16:0_20:2)(OR=1.092,P=0.001),triglyceride(52:5)(OR=1.090,P=0.001),triglyceride(51:3)(OR=1.081,P=0.001),triglyceride(52:3)(OR=1.052,P=0.023),and sphingomyelin(d36:1)(OR=1.046,P=0.031)were potential risk factors for BD,while phosphatidylethanolamine(O-16:1_22:5)(OR=0.931,P=0.004)is a protective factor for BD.Conclusion:The potential causal association between the plasma lipidome and BD,but the specific mechanisms still need further experimental research to validate.
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