类风湿性关节炎与乳腺癌因果关联:两样本孟德尔随机化研究和荟萃分析
Causal relationship between rheumatoid arthritis and breast cancer:a two-sample Mendelian randomization study and Meta-analysis
赵娜 1刘治璞 1王洪星 1张义1
作者信息
- 1. 山东大学齐鲁医院 检验科,山东 济南 250012
- 折叠
摘要
目的:利用两样本孟德尔随机化(TSMR)和荟萃分析的方法探讨类风湿性关节炎(RA)与乳腺癌的因果关系.方法:采用逆方差加权(IVW)、加权中位数、Egger 回归、简单模式和加权模式方法,对在线可访问数据集进行TSMR分析,利用EBI数据库进行荟萃分析.结果:正向TSMR(OR=0.947,95％CI 0.914～0.982,P=0.003)和EBI数据库荟萃分析(OR=0.97,95％CI 0.96～0.99)表明,RA与乳腺癌患病风险具有因果关系.采用留一法剔除SNP后,TSMR分析结果稳健.反向TSMR结果表明,乳腺癌与RA不具有因果关系(OR=0.976,95％CI 0.936～1.019,P=0.268).结论:RA与乳腺癌之间存在负相关因果关系,这为揭示RA与癌症患病风险的关系提供参考.
Abstract
Objective:To explore the causal relationship between rheumatoid arthritis(RA)and breast cancer by two-sample Mendelian randomization(TSMR)and Meta-analysis.Methods:Inverse variance weighting(IVW),weighted median,Egger regression,simple mode and weighted mode methods were used to perform TSMR analysis on online accessible data sets,and Meta-analysis was conducted using the EBI database.Results:Positive TSMR(OR=0.947,95％CI 0.914-0.982,P=0.003)and EBI database Meta-analysis(OR=0.97,95％CI 0.96-0.99),indicating that RA had a causal relationship with the risk of breast cancer.After using the leave-one-out method to eliminate SNPs,the TSMR analysis results were robust.The reverse TSMR results showed that there was no causal relationship between breast cancer and RA(OR=0.976,95％CI 0.936-1.019,P=0.268).Conclusion:There is a negative causal relationship between RA and breast cancer,which provides a reference for revealing the relationship between RA and the risk of cancer.
关键词
类风湿性关节炎/乳腺癌/孟德尔随机化/因果关系/荟萃分析Key words
rheumatoid arthritis/breast cancer/Mendelian randomization/causal relationship/Meta-analysis引用本文复制引用
出版年
2024
NETL
NSTL
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