Objective:To explore the causal relationship between rheumatoid arthritis(RA)and breast cancer by two-sample Mendelian randomization(TSMR)and Meta-analysis.Methods:Inverse variance weighting(IVW),weighted median,Egger regression,simple mode and weighted mode methods were used to perform TSMR analysis on online accessible data sets,and Meta-analysis was conducted using the EBI database.Results:Positive TSMR(OR=0.947,95％CI 0.914-0.982,P=0.003)and EBI database Meta-analysis(OR=0.97,95％CI 0.96-0.99),indicating that RA had a causal relationship with the risk of breast cancer.After using the leave-one-out method to eliminate SNPs,the TSMR analysis results were robust.The reverse TSMR results showed that there was no causal relationship between breast cancer and RA(OR=0.976,95％CI 0.936-1.019,P=0.268).Conclusion:There is a negative causal relationship between RA and breast cancer,which provides a reference for revealing the relationship between RA and the risk of cancer.
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