Relationship between the distribution of sputum pathogens and the serum levels of SAA,IL-9 and sICAM-1with the severity and prognosis of respiratory tract infection
Objective:To exploring the distribution of pathogenic bacteria in sputum of patients with respiratory infections and the relationship between serum amyloid A protein(SAA),interleukin-9(IL-9),soluble intercellular adhesion molecule-1(sICAM-1)levels and the severity and prognosis of the disease.Methods:A retrospective selection was conducted on 81 patients with respiratory tract infections who visited our hospital from June 2022 to June 2023.The control group consisted of 81 healthy individuals who underwent physical examinations during the same period.The infected individuals were followed up for six month.The distribution of sputum pathogens,levels of SAA,IL-9,and sICAM-1 under different degrees of illness were compared as well as the impact of the three indicators on prognosis.Results:A total of 105 pathogenic strains were isolated from the sputum of 81 patients through pathogen culture,among which Gram-negative bacteria were the most numerous,accounting for 61.90％(65/105),followed by Gram-positive bacteria at 26.67％(28/105),and fungi accounting for 11.43％(12/105).The expression levels of SAA,IL-9,and sICAM-1 in the infected group were higher than those in the healthy group(P<0.001).Among infected patients,the levels of SAA,IL-9,and sICAM-1 were higher in moderate infections compared with tomild infections,with significant differences(P<0.05).After follow-up,there were no statistically significant differences in gender,age,smoking history,drinking history coronary heart disease,hypertension,and diabetes between the recurrent and non recurrent groups(P>0.05).However,there were statistically significant differences in symptom severity,SAA,IL-9,and sICAM-1,which were related factors for recurrence(P<0.05).Logistic regression model analysis showed moderate symptoms,SAA≥85.00 mg·L-1,IL-9≥25.42 ng·L-1,and sICAM-1≥1.13 ng·mL-1were the risk factors for recurrence in patients with respiratory infections(P<0.05).Conclusion:Patients with moderate respiratory tract infections have more pathogenic bacteria in their sputum than those with mild infections,with Klebsiella pneumoniae,Pseudomonas aeruginosa,and Staphylococcus aureus being more common.The levels of SAA,IL-9,and sICAM-1 are higher in moderate infections than in mild infections.The degree of infection,expression levels of SAA,IL-9,and sICAM-1 can affect the recurrence of respiratory infection patients.
pathogenic bacteria in sputumserum amyloid A proteininterleukin-9soluble intercellular adhesion molecule-1severityprognosis
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