Objective:To evaluate the efficacy and safety of common Chinese medicinal prescriptions in the treatment of perimenopausal insomnia by network Meta-analysis(NMA).Methods:Prospective cohort study or RCT study of all common Chinese medicinal prescriptions for perimenopausal insomnia were searched from 7 databases including CNKI,Wanfang Database,VIP data,PubMed,Web of Science,Embase and Cochrane Library from database inception to December 31,2023.The quality of the included literatures was evaluated according to the strategies in the Cochrane Manual of Systematic Review.Stata 14.0 and Review Manager 5.4 were used to evaluate the total effective rate of perimenopausal insomnia symptom improvement,Pittsburgh Sleep Quality Index Scale(PSQI)score as well as safety.Results:A total of 21 papers including 1 589 patients were selected,involving 11 common Chinese medicine prescriptions.The results of NMA were that in terms of the total effective rate to the improvement of perimenopausal insomnia symptoms,Danggui Liuhuang Decoction(75.10％)had the best effect.In terms of improvement in PSQI score,Danggui Liuhuang Decoction(66.50％)had the best effect.In terms of safety,Danggui Liuhuang Decoction had the lowest probability of adverse reactions.Conclusion:For perimenopausal women,Danggui Liuhuang Decoction has advantages in improving the total effective rate and PQSI sore,and the probability of adverse effects is the lowest.However,more high-quality and large sample size studies are needed to further verify this conclusion.
Chinese medicinal prescriptionsperimenopauseinsomnianetwork Meta-analysis
NETL
NSTL
万方数据
