Objective:To investigate the expression of pre-B-cell leukemia homeobox 3(PBX3)in the bone marrow of patients with multiple myeloma(MM)and its relationship with prognosis.Methods:From January 2018 to July 2020,106 MM patients admitted to our hospital were selected as the study objects.The expression of PBX3 in bone marrow was detected by immunohistochemistry.Based on the expression of PBX3 in the bone marrow,patients were divided into PBX3 postive group(n=76)and PBX3 negative group(n=30).4 patients were lost to follow-up during the follow-up visits.Complying with the 3-year prognosis,MM patients were divided into survival group(n=63)and death group(n=39).The influencing factors of prognosis in MM patients were analyzed by Cox regression analysis.Kaplan-Meier method was used to plot the survival curves of MM patients with different PBX3 expression.Results:Compared with PBX3 negative group,the proportions of Durie-Salmon(DS)stage Ⅲ,international staging system(ISS)stage Ⅲ,lactate dehydrogenase(LDH)≥245 U·L-1 and platelet count(PLT)<100×109 L-1 were higher in PBX3 positive group(P<0.05).Multivariate Cox regression analysis showed that DS stage,ISS stage,risk stratification,β2-microglobulin(β2M),and PBX3 were all influencing factors for the prognosis of MM patients(P<0.05).The 3-year overall survival rate of PBX3 positive group(50.00％)was lower than that of PBX3 negative group(83.33％)(P<0.05).Conclusion:The positive expression rate of PBX3 in the bone marrow of MM patients is relatively high,and the expression of PBX3 is closely related to the clinical pathological features and prognosis.
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