首页|Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice

Tetrahydroxy Stilbene Glucoside Ameliorates Cognitive Impairments and Pathology in APP/PS1 Transgenic Mice

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Cognitive impairment is the main clinical manifestation of Alzheimer's disease (AD),and amyloid-β (Aβ) deposition and senile plaques are the characteristic neuropathological hallmarks in AD brains.This study aimed to explore the effect and mechanism of tetrahydroxy stilbene glucoside (TSG) on cognitive function in APP/PS1 mice during long-term administration.Here,we treated APP/PS1 model mice of AD with different doses of TSG (50 mg/kg and 100 mg/kg) for 5 to 17 months by gavage,and we further observed whether TSG could ameliorate the cognitive decline in APP/PS1 mice using behavioral tests,and investigated the possible mechanisms by immunohistochemistry and Western blotting.Our results showed that TSG treatment rescued the spatial and non-spatial learning and memory impairments of APP/PS1 mice at Morris water maze test and novel object recognition test.Furthermore,Aβ40/42 deposition in the cortex andhippocampus of APP/PS1 mice treated with TSG was significantly reduced compared to the wild type mice using the immunohistochemical technique.Finally,Western blotting showed that TSG primarily decreased the APP expression to avoid the Aβ plaque deposition in the cortex and hippocampus of mice.These results reveal the beneficial effects of TSG in APP/PS 1-AD mice,which may be associated with the reduction of Aβ deposits in the brain.

tetrahydroxy stilbene glucosideAPP/PS1 transgenic micecognitive impairmentsamyloid-β protein

Dan GAO、Chen CHEN、Rui HUANG、Cui-cui YANG、Bei-bei MIAO、Lin LI、Lan ZHANG

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Department of Pharmacy, Xuanwu Hospital of Capital Medical University

Key Laboratory for Neurodegenerative Diseases of Ministry of Education

Beijing Institute for Brain Disorders

Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, China

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National Natural Science Foundation of China"Major New Drug Creation" of Major Science and Technology ProjectCapital Science and Technology Leading Talent Training ProjectBeijing Hospitals Authority Ascent Plan

818035372015ZX09101-016Z191100006119017DFL20190803

2021

10.1007/s11596-021-2344-z

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(2)
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