首页|Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Copper Metabolism and Cuproptosis:Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Copper is an essential trace element,and plays a vital role in numerous physiological processes within the human body.During normal metabolism,the human body maintains copper homeostasis.Copper deficiency or excess can adversely affect cellular function.Therefore,copper homeostasis is stringently regulated.Recent studies suggest that copper can trigger a specific form of cell death,namely,cuproptosis,which is triggered by excessive levels of intracellular copper.Cuproptosis induces the aggregation of mitochondrial lipoylated proteins,and the loss of iron-sulfur cluster proteins.In neurodegenerative diseases,the pathogenesis and progression of neurological disorders are linked to copper homeostasis.This review summarizes the advances in copper homeostasis and cuproptosis in the nervous system and neurodegenerative diseases.This offers research perspectives that provide new insights into the targeted treatment of neurodegenerative diseases based on cuproptosis.

cuproptosiscopper metabolismcopper homeostasisneurodegenerationneuro-degenerative disease

Xiao-xia BAN、Hao WAN、Xin-xing WAN、Ya-ting TAN、Xi-min HU、Hong-xia BAN、Xin-yu CHEN、Kun HUANG、Qi ZHANG、Kun XIONG

展开 >

Department of Human Anatomy and Neurobiology,School of Basic Medical Science,Central South University,Changsha 430013,China

Department of Endocrinology,Third Xiangya Hospital,Central South University,Changsha 430013,China

Department of Dermatology,Xiangya Hospital,Central South University,Changsha 430013,China

Affiliated Hospital,Inner Mongolia Medical University,Hohhot 010050,China

Key Laboratory of Emergency and Trauma of Ministry of Education,Hainan Medical University,Haikou 571199,China

Hunan Key Laboratory of Ophthalmology,Changsha 430013,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Hunan ProvinceKey Laboratory of Emergency and Trauma of Ministry of EducationKey Laboratory of Emergency and Trauma of Ministry of Education

8197189182172196823725072023JJ40804Hainan Medical UniversityKLET-202210

2024

10.1007/s11596-024-2832-z

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(1)
  • 256