首页|Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Objective:Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains unclear.In the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were explored.Methods:In total,35 patients were enrolled in the study following an outbreak of H AdV-7 in the army,of whom 14 had pneumonia and 21 had URTI.Blood samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted metabolomics.Results:Over 90％of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and sphingolipids.The metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid metabolism.The sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI patients.Ceramide and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion:Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

human adenovirusmetabonomiclipidspneumoniaupper respiratory tract infection

Ting-ting WEI、Wen XU、Bo TU、Wan-xue ZHANG、Xin-xin YANG、Yiguo ZHOU、Shan-shan ZHANG、Jun-lian YANG、Ming-zhu XIE、Juan DU、Wei-wei CHEN、Qing-bin LU

展开 >

Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China

Department of Infectious Disease,The Fifth Medical Center of Chinese PLA General Hospital,National Clinical Research Center for Infectious Diseases,Beijing 100039,China

Department of Laboratorial Science and Technology & Vaccine Research Center,School of Public Health,Peking University,Beijing 100191,China

Department of Health Policy and Management,School of Public Health,Peking University,Beijing 100191,China

Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group,Peking University,Beijing 100191,China

Key Laboratory of

展开 >

National Natural Science Foundation of ChinaJoint Research Fund for Beijing Natural Science Foundation and Haidian Original InnovationFundamental Research Funds for the Central Universities and Peking University Health Science CenterPeking University Medicine Fund of Fostering Young Scholars'Scientific &Technological Innovation

82073617L202007BMU2021YJ041BMU2021PY005

2024

10.1007/s11596-024-2835-9

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(1)
  • 42