首页|Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

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Extracellular vesicles(EVs)are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity,natural functionality,and excellent biocompatibility.However,limitations such as low uptake efficiency,insufficient production,and inhomogeneous performance undermine their potential.To address these issues,numerous researchers have put forward various methods and applications for enhancing EV uptake in recent decades.In this review,we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV uptake.In addition,we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

extracellular vesiclesexosomesextracellular vesicle uptakeextracellular vesicle-based therapy

Ying-peng XU、Tao JIANG、Xiao-fan YANG、Zhen-bing CHEN

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Department of Hand Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of China

8237083882172221

2024

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子:0.748
ISSN:2096-5230
年,卷(期):2024.44(2)
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