首页|Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis

Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis

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Recent studies have shown that cellular levels of polyamines(PAs)are significantly altered in neurodegenerative diseases.Evidence from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress,mitochondrial metabolism,cellular immunity,and ion channel functions.Dysfunction of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative diseases.Therefore,in the current work,evidence was collected to determine the possible associations between cellular levels of PAs,and related enzymes and the development of several neurodegenerative diseases,which could provide a new idea for the treatment of neurodegenerative diseases in the future.

polyamineapoptosismitochondrianeurodegenerative disease

Xin-tong JI、Wen-lei YU、Meng-jia JIN、Lin-jie LU、Hong-ping YIN、Huan-huan WANG

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School of Basic Medical Sciences,Affiliated Hospital of Hangzhou Normal University,Hangzhou Normal University,Hangzhou 311121,China

School of Medicine,Chongqing University,Chongqing 400030,China

Department of Stomatology,Huzhou Wuxing District People's Hospital,Huzhou Wuxing District Maternal and Child Health Hospital,Huzhou 313008,China

School of Pharmacy,Zhejiang University,Hangzhou 310030,China

Department of Stomatology,Haining Hospital of Traditional Chinese Medicine,Jiaxing 314400,China

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Zhejiang Provincial Natural Science Foundation of ChinaZhejiang Medical Health Science and Technology Project of China

LY19H2600032024KY1661

2024

10.1007/s11596-024-2843-9

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(2)
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