首页|Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy:A New Technique for Selective Clamping of the Portal Vein

Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy:A New Technique for Selective Clamping of the Portal Vein

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Objective:A novel technique was explored using an airbag-selective portal vein blood arrester that circumvents the need for an intraoperative assessment of anatomical variations in patients with complex intrahepatic space-occupying lesions.Methods:Rabbits undergoing hepatectomy were randomly assigned to 4 groups:intermittent portal triad clamping(PTC),intermittent portal vein clamping(PVC),intermittent portal vein blocker with an airbag-selective portal vein blood arrester(APC),and without portal blood occlusion(control).Hepatic ischemia and reperfusion injury were assessed by measuring the 7-day survival rate,blood loss,liver function,hepatic pathology,hepatic inflammatory cytokine infiltration,hepatic malondialdehyde levels,and proliferating cell nuclear antigen levels.Results:Liver damage was substantially reduced in the APC and PVC groups.The APC animals exhibited transaminase levels similar to or less oxidative stress damage and inflammatory hepatocellular injury compared to those exhibited by the PVC animals.Bleeding was significantly higher in the control group than in the other groups.The APC group had less bleeding than the PVC group because of the avoidance of portal vein skeletonization during hepatectomy.Thus,more operative time was saved in the APC group than in the PVC group.Moreover,the total 7-day survival rate in the APC group was higher than that in the PTC group.Conclusion:Airbag-selective portal vein blood arresters may help protect against hepatic ischemia and reperfusion injury in rabbits undergoing partial hepatectomy.This technique may also help prevent liver damage in patients requiring hepatectomy.

hepatectomyportal veinhepatic damageselective clamping

Ce-xiong FU、Xiao-ri QIN、Jin-song CHEN、Jie ZHONG、Yu-xu XIE、Bi-dan LI、Qing-qing FU、Fang LI、Jin-fang ZHENG

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Department of Hepatobiliary and Pancreatic Surgery,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China

University of South China,Hengyang 421001,China

Department of Gastroenterology,Gastroenterology Endoscopy Center,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China

Center of Clinical Laboratory,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China

Department of Radiology,Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University,Haikou 570311,China

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Hainan Provincial Natural Science Foundation of ChinaHainan Provincial Natural Science Foundation of China

821QN09822019RC373

2024

10.1007/s11596-024-2837-7

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(2)
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