首页|Research Progress on the Pathogenesis and Treatment of Neoathero-sclerosis
Research Progress on the Pathogenesis and Treatment of Neoathero-sclerosis
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Neoatherosclerosis(NA)within stents has become an important clinical problem after coronary artery stent implantation.In-stent restenosis and in-stent thrombosis are the two major complications following coronary stent placement and seriously affect patient prognosis.As the common pathological basis of these two complications,NA plaques,unlike native atherosclerotic plaques,often grow around residual oxidized lipids and stent struts.The main components are foam cells formed by vascular smooth muscle cells(VSMCs)engulfing oxidized lipids at lipid residue sites.Current research mainly focuses on optical coherence tomography(OCT)and intravascular ultrasound(1VUS),but the specific pathogenesis of NA is still unclear.A thorough understanding of the pathogenesis and pathological features of NA provides a theoretical basis for clinical treatment.This article reviews the previous research of our research group and the current situation of domestic and foreign research.
neoatherosclerosisvascular smooth muscle cells
Yi-shan GUO、Ning YANG、Zhen WANG、Yu-miao WEI
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Department of Cardiology,Hubei Key Laboratory of Biological Targeted Therapy,Hubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
Department of Cardiology,Binzhou Medical University Hospital,Binzhou 256600,China
Department of Gynecology,Binzhou Medical University Hospital,Binzhou 256600,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of China
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