首页|Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity

Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity

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Objective:Inflammation is involved in the development and progression of nonalcoholic fatty liver disease(NAFLD).The monocyte to high-density lipoprotein cholesterol ratio(MHR)has emerged as a marker for various inflammation-related diseases.The aim of the present study was to investigate the association between the MHR and NAFLD in a population with childhood obesity.Methods:Based on hepatic ultrasound,a total of 504 children with obesity(357 with NAFLD and 147 without NAFLD)were included in the study.The correlation between the MHR and NAFLD risk factors was assessed by Pearson's and Spearman's analyses.Multivariate stepwise logistic regression analyses were conducted to explore the association between the MHR and the risk of NAFLD.Results:The MHR in patients with NAFLD was significantly greater than that in patients without NAFLD[0.52(0.44-0.67)versus 0.44(0.34-0.57),P＜0.001].Multivariate stepwise logistic regression analysis demonstrated that the MHR[odds ratio(OR):1.033,95％confidence interval(CI):1.015-1.051;P＜0.001]was an independent predictor of NAFLD in childhood obesity patients,as were age(OR:1.205,95％CI:1.059-1.371;P=0.005],waist circumference[OR:1.037,95％CI:1.008-1.067;P=0.012],and alanine transaminase[OR:1.067,95％CI:1.045-1.089;P＜0.001].Additionally,MHR quartiles showed a significant positive association with the incidence of NAFLD after adjusting for potential confounding factors.Conclusion:The present study showed that the MHR may serve as an available and useful indicator of NAFLD in individuals with childhood obesity.

nonalcoholic fatty liver diseaseobesitymonocyte-to-high-density lipoprotein ratiomarker

Jun-feng ZHANG、Feng-qing CAI、Xiu-cai ZHANG、Qing YE

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Department of Laboratory Medicine,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310052,China

Natural Science Foundation of Zhejiang ProvinceKey Project of Provincial Ministry Construction,Health Science and Technology Project Plan of Zhejiang ProvinceKey Laboratory of Women's Reproductive Health Research of Zhejiang ProvinceNational Natural Science Foundation of ChinaKey Research and Development Plan of Zhejiang Province

LY22H050001WKJ-ZJ-2128ZDFY2020-RH-0006U20A203512021C03079

2024

10.1007/s11596-024-2919-6

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(4)