首页|Rates,Risk Factors,and Outcomes of Nonvariceal Upper Gastrointestinal Bleeding in Patients Hospitalized for CO VID-19 in the United States

Rates,Risk Factors,and Outcomes of Nonvariceal Upper Gastrointestinal Bleeding in Patients Hospitalized for CO VID-19 in the United States

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Objective:This study aimed to investigate the incidence and predictors of non-variceal upper gastrointestinal bleeding(NVUGIB)in hospitalized patients with coronavirus disease 2019(COVID-19),as well as the inpatient outcomes associated with this complication.Methods:This was an analysis of the National Inpatient Sample Database from January to December 2020.Adult COVID-19 patients were categorized into two groups based on NVUGIB development during hospitalization.Multivariate logistic analysis was performed to identify predictors and outcomes associated with NVUGIB in hospitalized COVID-19 patients in the US,after adjusting for age,sex,race,and Charlson Comorbidity Index(CCI)score,using Stata/BE 17.0.Results:Among 1 050 045 hospitalized patients,1.87％developed NVUGIB.Asian Americans had the highest risk,followed by Native Americans,Hispanics,and African Americans,with odds ratios(ORs)of 1.70,1.59,1.40,and 1.14,respectively.Patients with higher CCI scores were also at greater risk(with ORs of 1.47,2.09,and 3.45 for CCI scores of 1,2,and 3,respectively).COVID-19 patients with NVUGIB had a higher risk of inpatient mortality(OR=3.84),acute kidney injury(OR=3.12),hypovolemic shock(OR=13.7),blood transfusion(OR=7.02),and in-hospital cardiac arrest(OR=4.02).Conclusion:NVUGIB occurred in 1.87％of hospitalized COVID-19 patients and was associated with a threefold increase in mortality.Further research is necessary to identify strategies for reducing its incidence in COVID-19 patients with multiple risk factors.

COVID-19upper gastrointestinal bleedingepidemiologypredictorsoutcomes

Mohammad Aldiabat、Wesam Aleyadeh、Taimur Muzammil、Kemi Adewuyi、Majd Alahmad、Ahmad Jabri、Laith Alhuneafat、Yassine Kilani、Saqr Alsakarneh、Mohammad Bilal

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Harvard T.H.Chan School of Public Health,Harvard University,Boston 02115,USA

Department of Medicine,Cleveland Clinic Akron General,Akron 44307,USA

Department of Medicine,Allegheny Health Network,Pittsburgh 15212,USA

Department of Medicine,University of Pittsburgh,Pittsburgh 15261,USA

Heart and Vascular Center,MetroHealth Medical Center,Cleveland 44109,USA

Department of Medicine,Lincoln Medical Center/Weil Cornell Medicine,Bronx 10451,USA

Department of Medicine,University of Missouri-Kansas City,Kansas City 64108,USA

Department of Medicine,University of Minnesota/Minneapolis VA Medical Center,Minneapolis 55417,USA

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2024

10.1007/s11596-024-2838-6

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(6)