首页|Genome-integrated Human Papilloma Viruses Testing:A Complement to Colposcopy-guided Biopsy for Cervical Cancer Screening

Genome-integrated Human Papilloma Viruses Testing:A Complement to Colposcopy-guided Biopsy for Cervical Cancer Screening

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Objective:Our research aims to evaluate the diagnostic accuracy of colposcopy-guided biopsy(CGB)in detecting high-grade cervical lesions and explore how human papilloma virus(HPV)integration status and other factors affect its performance.Methods:A retrospective cohort analysis involving 550 patients was conducted to evaluate whether the HPV integration plays a role in identifying high-grade cervical lesions and cervical cancer.Logistic regression models and area under the curve(AUC)calculations were employed.Results:Our findings revealed that 53.5％of CGB/surgery pairs demonstrated congruent diagnoses,whereas 17.1％showed underestimation and 29.5％overestimation.Furthermore,multivariate logistic regression analysis identified several key predictors for cervical intraepithelial neoplasia(CIN)2+and CIN3+according to surgical pathology.Notably,a CGB confirming CIN2+[odds ratio(OR)=6.0,95％confidence interval(CI):3.9-9.1,P＜0.001],high-grade cytology(OR=2.6,95％CI:1.4-4.9,P=0.003),and HPV integration positivity(OR=2.2,95％CI:1.3-3.5,P＜0.001)emerged as significant factors for CIN2+.Similarly,for CIN3+identification,CGB confirming CIN2+(OR=5.3,95％CI:3.4-8.3,P＜0.001),high-grade cytology(OR=2.6,95％CI:1.5-4.7,P=0.001),and HPV integration positivity(OR=2.0,95％CI:1.3-3.1,P=0.003)were independent predictors.Conclusion:Our study highlights the innovative role of HPV integration testing as a pivotal adjunct to CGB and cytology,offering a comprehensive approach that may enhance the diagnostic precision for high-grade cervical lesions,ultimately achieving more precise management strategies.

uterine cervical dysplasiahuman papilloma virushuman papillomavirus virus integrationcolposcopy-guided biopsydiagnostic performance

Han XIE、Li LI、Tao ZHU、Hu ZHOU、Liang HE、Fan YANG、Shi-min CHEN、Xiao-yuan HUANG、Ding MA、Ting HU、Liang ZHUANG

展开 >

Department of Gynaecological Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

National Clinical Research Centre for Obstetrics and Gynaecology,Cancer Biology Research Centre(Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Wuhan KDWS Biological Technology Co.,Ltd,New Technology Platform,Wuhan 430200,China

Cancer Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

展开 >

2024

10.1007/s11596-024-2947-2

当代医学科学(英文)
华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748
ISSN：2096-5230
年,卷(期)：2024.44(6)