Causal Link between Gut Microbiota and Infertility:A Two-sample Bidirectional Mendelian Randomization Study

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外文摘要：Objective:To investigate the associations of the gut microbiota with reproductive system diseases,including female infertility,male infertility,polycystic ovary syndrome(PCOS),primary ovarian failure,endometriosis,uterine fibroids,uterine polyps,sexual dysfunction,orchitis,and epididymitis.Methods:A two-sample bidirectional Mendelian randomization(MR)analysis was performed to evaluate the potential causal relationship between the composition of gut microbiota and infertility,along with associated diseases.Results:Sixteen strong causal associations between gut microbes and reproductive system diseases were identified.Sixty-one causal associations between gut microbes and reproductive system diseases were determined.The genus Eubacterium hallii was a protective factor against premature ovarian failure and a pathogenic factor of endometriosis.The genus Erysipelatoclostridium was the pathogenic factor of many diseases,such as PCOS,endometriosis,epididymitis,and orchitis.The genus Intestinibacter is a pathogenic factor of male infertility and sexual dysfunction.The family Clostridiaceae 1 was a protective factor against uterine polyps and a pathogenic factor of orchitis and epididymitis.The results of reverse causal association analysis revealed that endometriosis,orchitis,and epididymitis all led to a decrease in the abundance of bifidobacteria and that female infertility-related diseases had a greater impact on gut microbes than male infertility-related diseases did.Conclusions:The findings from the MR analysis indicate that there is a bidirectional causal relationship between the gut microbiota and infertility as well as associated ailments.Compared with ovarian diseases,uterine diseases are more likely to lead to changes in women's gut microbiota.The findings of this research offer valuable perspectives on the mechanism and clinical investigation of reproductive system diseases caused by microorganisms.

外文关键词：

gut microbiotainfertilityMendelian randomizationovarianuterinesexual dysfunctionorchitisepididymitis

作者：

Jia-xin ZHANG、Qin-lan LI、Xiao-yan WANG、Cheng-chang ZHANG、Shu-ting CHEN、Xiao-hang LIU、Xin-yi DONG、Hu ZHAO、Dong-hui HUANG

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作者单位：

Institute of Reproduction Health Research,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Reproductive Center,Qingdao Women and Children's Hospital Affiliated to Qingdao University,Qingdao 266034,China

Department of Human Anatomy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

National Demonstration Center for Experimental Basic Medical Education,Huazhong University of Science and Technology,Wuhan 430030,China

Shenzhen Huazhong University of Science and Technology Research Institute,Shenzhen 518109,China

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出版年：

2024

DOI：

10.1007/s11596-024-2931-x

当代医学科学(英文)

华中科技大学同济医学院

当代医学科学(英文)

影响因子：0.748

ISSN：2096-5230

年,卷(期)：2024.44(6)