Research Progress of Cell Pyroptosis in Renal Ischemia-Reperfusion Injury
Renal ischemia-reperfusion injury(IRI)is one of the main causes of acute kidney injury,for which there is no ef-fective treatment.Therefore,exploring the mechanism of renal IRI and discovering effective targeted drugs are of great signifi-cance.Pyroptosis is a newly discovered form of inflammatory programmed cell death.Studies have found that cell pyroptosis is closely related to the occurrence and development of renal IRI.This article reviews functions and its mechanism of pyroptosis in renal IRI,and discusses the new research progress in the application of related drugs affecting pyroptosis in renal IRI,providing new ideas for the treatment of renal ischemia-reperfusion injury.
pyroptosisrenal ischemia-reperfusion injurytargeted drug
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