Effect of Sympathetic Nerve on Neuropathic Spontaneous Pain
Spontaneous pain is continuous or paroxysmal pain that is not related to an external stimulus.It is one of the main clinical manifestations of neuropathic pain.Due to its complex pathogenesis and lack of effective treatment measures,spon-taneous pain brings great trouble to patients with neuropathic pain.It has been revealed that neuropathic spontaneous pain is re-lated to dysfunction of sympathetic nervous system.In clinical medicine,neuropathic spontaneous pain could be depressed by sympathetic nerve block or sympathectomy,suggesting that sympathetic nerve is involved in the generation and maintenance of neuropathic spontaneous pain.In this review,peripheral and central nervous system plasticity changes and mediators basis relat-ed to sympathetic nerve mediating neuropathic spontaneous pain will be reviewed.Hopefully it might provide more ideas for clinical treatment of neuropathic spontaneous pain.
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