Objective To explore association between serum uric acid(SUA)in early pregnancy and the subsequent risk of preeclampsia during pregnancy.Methods In this cohort study,2875 pregnant women who went to obstetrics department of Renmin Hospital of Wuhan University from January 2017 to December 2021 were retrospectively included.Univariate and mult-ivariate penalized smoothing splines cox regression was applied to model the association of serum UA with risk of preeclamp-sia.Results Non-linear associations between serum UA and preeclampsia risk were observed,and there was a U-shaped associ-ation of uric acid with the risk of preeclampsia in pregnant women.pregnant women had the lowest risk of PE when SUA=282μmol/L.The cox regression result showed that the risk of preeclampsia in pregnant women with SUA levels＜220 μmol/L or≥325 μmol/L in the first trimester was 2.72 times(95％CI:1.83-4.05)or 2.82 times(95％CI:1.88-4.22)than those with uric acid levels of 275-299 μmol/L.Conclusion There is a U-shaped association between serum UA levels in early pregnancy and preeclampsia.Either too high or too low SUA will increase the risk of PE.
NETL
NSTL
万方数据
