性激素和性激素结合球蛋白与高尿酸血症及痛风关系的研究进展
Progress of Sex Hormones and Sex Hormone-binding Globulin Involved in Hyperuricemia and Gout
蒋铫瑶 1邱康丽 1廖云飞1
作者信息
- 1. 华中科技大学同济医学院附属协和医院内分泌科,武汉 430022
- 折叠
摘要
全球范围内高尿酸血症及痛风的患病率持续上升,会进一步导致慢性肾病、心脑血管疾病以及关节疾病等并发症,造成巨大的社会负担.已有多个研究报道痛风发病具有性别差异,但性激素这类两性生物标志物与高尿酸血症或痛风的关系近年来才逐渐引起重视,且在结果及机制上仍存在争议.该文综合阐述了性激素对高尿酸血症及痛风影响的研究进展,主要包括雌激素、雄激素、孕激素和性激素结合球蛋白(sex hormone-binding globulin,SHBG)与高尿酸血症及痛风的关系,以及潜在机制,为进一步明确尿酸代谢机制以及痛风的早期防治提供依据.
Abstract
The prevalence of hyperuricemia and gout is continuously increasing on a global scale,leading to increased social burden through complications such as chronic kidney disease,cardiovascular diseases,and joint disorders.Several studies have reported gender differences in the onset of gout,but the relationship between sex hormones as biologic markers and hyperurice-mia or gout has just gained attention in recent years,with ongoing debates on its authenticity and mechanisms.This article com-prehensively elaborates on the research progress in the impact of estrogen,androgen,progesterone,and sex hormone-binding globulin(SHBG)on hyperuricemia and gout,as well as underlying mechanisms.It will provide a basis for further understanding of uric acid metabolism and early prevention and treatment of gout.
关键词
痛风/高尿酸血症/性激素/性激素结合球蛋白/孟德尔随机化Key words
gout/hyperuricemia/sex hormone/sex hormone-binding globulin/mendelian randomization引用本文复制引用
基金项目
国家自然科学基金资助项目(82070830)
湖北省重点研发计划资助项目(2022BCA036)
出版年
2024
NETL
NSTL
万方数据