Progress of Sex Hormones and Sex Hormone-binding Globulin Involved in Hyperuricemia and Gout
The prevalence of hyperuricemia and gout is continuously increasing on a global scale,leading to increased social burden through complications such as chronic kidney disease,cardiovascular diseases,and joint disorders.Several studies have reported gender differences in the onset of gout,but the relationship between sex hormones as biologic markers and hyperurice-mia or gout has just gained attention in recent years,with ongoing debates on its authenticity and mechanisms.This article com-prehensively elaborates on the research progress in the impact of estrogen,androgen,progesterone,and sex hormone-binding globulin(SHBG)on hyperuricemia and gout,as well as underlying mechanisms.It will provide a basis for further understanding of uric acid metabolism and early prevention and treatment of gout.
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