摘要
卵巢作为女性重要的生殖器官,不仅为人类繁衍提供配子,还分泌多种激素参与全身多系统功能的支持和维护.卵巢功能下降表现为生育力低下、早绝经等,甚至会导致多器官功能障碍,严重危害女性健康.微量元素在维持卵巢功能中起着重要作用,卵巢细胞内微量元素稳态失衡会引起酶活性降低、激素分泌失调、排卵障碍以及生殖器官的组织结构变化等,从而导致卵巢功能下降.深入研究微量元素在卵巢功能调控中的作用及机制,有利于从本质上理解卵巢的生理功能并预防其功能紊乱的发生.该文结合近年国内外关于微量元素应用的研究,综述了微量元素(铁、锌、铜、硒、碘、钴、铬、钼)与卵巢功能的关系,以及微量元素影响卵巢功能的作用机制,以期为研究微量元素在卵巢功能中的作用提供理论依据.
Abstract
Ovary is a vital female gonadal organ.It not only provides gametes for reproduction,but also secretes hormones to support and maintain the function of multiple systems.The decline of ovarian function is characterized by low fertility,early menopause,etc.It may even lead to dysfunction of multiple organs,which seriously damage women's health.Trace elements(TEs)play an important role in maintaining the normal ovarian function.When the TEs are unbalanced and cannot keep the ho-meostasis of ovary,inducing hormone secretion disorder,ovulatory disorder,decreased enzyme activity and histological changes of ovary.These changes lead to diminished ovarian function.Therefore,in-depth study on the role and mechanism of TEs in the regulation of ovarian function is conducive to understand the physiological function and prevent ovarian dysfunction.In this re-view,in combination with the research on the application of TEs at home and abroad in recent years,the relationship between TEs(iron,zinc,copper,selenium,iodine,cobalt,chromium,molybdenum)and ovarian function,as well as the mechanism of TEs affecting ovarian function are summarized,which will provide some theoretical guidance for the study of TEs in ovarian function in the future.
基金项目
国家自然科学基金资助项目(81873824)
国家自然科学基金资助项目(82001514)
国家重点研发计划资助项目(2023YFC2706003)
NETL
NSTL
万方数据