摘要
组蛋白修饰在急性心肌梗死(AMI)的发生、发展中起重要作用.AMI发生时,由于供能不足,心肌细胞主要供能的细胞器——线粒体无法正常合成ATP,从而发生线粒体功能障碍,进而诱导心肌细胞发生细胞焦亡;此外细胞凋亡同样在AMI的发生发展中扮演重要角色.组蛋白修饰包括甲基化、乙酰化、磷酸化、乳酸化等机制,这些多样化的修饰在心肌梗死的发生发展过程中相互协作又相互拮抗,形成一个复杂的调控网络.组蛋白修饰通过调控相关基因表达缓解炎症反应诱导的细胞焦亡及细胞凋亡,从而影响AMI的发病进程.该文主要就组蛋白修饰在AMI发病机制中的研究进展进行综述.
Abstract
Histone modification plays an important role in the occurrence and development of acute myocardial infarction(AMI).When AMI occurs,due to the lack of energy supply,the main energy-supplying organelle of cardiomyocytes,mitochon-dria,cannot synthesize ATP normally,which leads to mitochondrial dysfunction,which can induce the apoptosis of cardiomyo-cytes.In addition,apoptosis also plays an important role.Histone modification includes methylation,acetylation,phosphoryla-tion,lactylation and other mechanisms.These diverse modifications cooperate and antagonize each other in the occurrence and development of myocardial infarction,forming a complex regulatory network.Histone modification can alleviate the apoptosis and focal death induced by inflammation by regulating the expression of related genes,thus affecting the pathogenesis of AMI.In this paper,the research progress of histone modification in the pathogenesis of acute myocardial infarction was re-viewed.
维普
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