Idiopathic pulmonary fibrosis(IPF)is a common interstitial fibrosis disease with poor prognosis and lack of effec-tive treatment to prolong the survival time of patients.Cell senescence can induce tissue inflammation and accelerate the patho-logical process of fibrosis.Excessive oxidative stress,nuclear DNA damage and mitochondrial dysfunction in the pathological en-vironment of IPF are the main causes of cell senescence.Nicotinamide adenine dinucleotide(NAD+)is an important coenzyme in redox reaction,which can regulate a series of biological functions by blocking cell senescence.Its active expression is closely re-lated to the occurrence and development of IPF.Therefore,to explore the mechanism of NAD+regulating cell senescence under pathological condition is of great significance for the prevention and treatment of IPF.
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