Osteoarthritis is the most common degenerative disease in humans,the pathogenesis of which is still un-clear.Mitochondrial impairment dysfunction plays an important role in human aging and degenerative diseases,therefore main-taining mitochondrial functional homeostasis is a potential therapeutic target for OA.Mitophagy is a process of targeted clear-ance and phagocytic dysregulated or damaged mitochondria to maintain mitochondrial homeostasis,which suggests that the reg-ulation of mitophagy may be a potential mechanism of OA treatment.In this paper,through reviewing the recently published lit-erature about mitophagy and OA,the role of mitophagy in the pathogenesis of OA is discussed,providing theoretical research for mitophagy,and emphasizing the potential of targeting autophagy to treat degenerative joint diseases.
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