Clinical study on the treatment of chronic atrophic gastritis with Zhishi Xiaopi pill combined with lansoprazole enteric-coated tablets
Objective:To observe the clinical curative effect of the Zhishi Xiaopi pill combined with lansoprazole enteric-coated tablets in treating chronic atrophic gastritis.Methods:64 patients with chronic atrophic gastritis admitted to our hospital from December 2021 to June 2022 were randomly divided into a control group and a treatment group,with 32 patients in each group.The patients in the control group were orally administered lansoprazole enteric-coated tablets(30 mg/time)once a day.The patients in the treatment group were orally administered with Zhishi Xiaopi pill 6 g/time,three times a day.The treatment course of both groups was five weeks.The clinical efficacy,symptom score,and improvement of inflammatory factors and serum oxidative stress levels were compared between the two groups.Results:The total effective rate of the control and treatment groups was 78.13%and 90.63%,respectively,and the difference between the two groups was statistically significant(P＜0.05).Symptom scores of fatigue,dull pain,gastric distension,and poor appetite were significantly decreased in both groups after treatment(P＜0.05),and the treatment group was lower than the control group after treatment,with statistical significance(P＜0.05).The inflammatory factors tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)in the treatment group were significantly lower than those in the control group before and after treatment(P＜0.05),and the difference was statistically significant(P＜0.05).The levels of serum superoxide dismutase(SOD)and nitric oxide(NO)in two groups after treatment were significantly higher than those before treatment(P＜0.05).After treatment,the treatment group was higher than the control group,and the difference between the two groups was statistically significant(P＜0.05).Conclusion:Zhishi Xiaopi pill combined with lansoprazole is effective in treating chronic atrophic gastritis,which can effectively reduce the inflammatory index and improve the stress index of patients.It can also be used in clinics.
万方数据
维普
