Comparison of clinical efficacy and safety of different doses of ambroxol in the treatment of pertussis in infants
Objective:To investigate the clinical effect and safety of different doses of ambroxol in treating pertussis in in-fants.Methods:114 children with pertussis admitted to the hospital from May 2020 to November 2022 were selected as the study objects and divided into two groups according to the random number table method,with 57 cases in each group.Both groups were given symptomatic treatment,such as back patting,sputum suction,and oxygen inhalation by mask.Based on these,the control group was given 7.5 mg of ambroxol mixed with 5%glucose injection intravenously twice/d,while the obser-vation group was given 10 mg of ambroxol mixed with 5%glucose injection intravenously twice/d.Both groups were treated for 14 days.The clinical efficacy and duration of clinical symptoms in the two groups were observed,and the changes in scores of cough symptoms and levels of inflammatory factors in the two groups were compared before treatment and after 14 days of treatment.The incidence of adverse reactions after medication was calculated.Results:The total effective rate of the observation group was 94.74%(54/57),higher than that of the control group(77.19%,44/57).The difference was statistically significant(P＜0.05).The duration of pulmonary rales,spastic cough,blood oxygen saturation decline,and hospital stay in the observation group were significantly shorter than those in the control group,with statistical significance(P＜0.05).Before treatment,there was no statistically significant difference in the cough symptom score,serum interleukin-6(IL-6),interleukin-17(IL-17),and tumor necrosis factor-α(TNF-α)levels between the two groups(P＞0.05).After treatment,the cough symptom score,IL-6,IL-17,and TNF-α in observation group were lower than those in the control group,with statistical significance(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the observation and control groups(P＞0.05).Conclusion:Compared with the conventional dose,the efficacy and safety of high-dose ambroxol for treating pertussis in infants are more significant,and it is worthwhile to promote the use of this drug in clinical practice.
pertussis in infantsambroxoldifferent dosesclinical efficacycough symptomsadverse reactionsinflam-matory factor
万方数据
维普
