Valproic acid(VPA)is a commonly used prescription drug.It is used in various dosage forms to treat complex partial seizures,absence seizures,bipolar affective disorder,and migraine prevention.VPA is generally well tolerated with mild adverse reactions,while VPA encephalopathy,that a few patients will suffer from coma,brain edema,and death,is a rare but severe complication of VPA,which is easily ignored in clinical practice,leading to delayed diagnosis and treatment and life-threatening.VPA encephalopathy is reversible if it can be identified and treated early.Early recognition and treatment of VPA encephalopathy is critical.This article reviews the epidemiology,clinical characteristics,pathogenesis,risk factors,diagnosis,and treatment related to VPA encephalopathy,providing reference for clinical practice.
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