Clinical study of bronchoalveolar lavage in early intervention of severe mycoplasma pneumonia in children
To explore the clinical effects of bronchoalveolar lavage as an early intervention for severe mycoplasma pneumonia(SMPP)in children.Methods:94 children with SMPP admitted to the hospital between June 2021 and March 2023 were selected and divided into groups based on whether their legal guardians had received bronchoalveolar lavage treatment.Children who agreed to undergo bronchoalveolar lavage were included in the treatment group(n=45),and those who disagreed were included in the control group(n=49).Both groups of children were treated with azithromycin,nebulization,and expectorant therapy.The treatment group underwent bronchoalveolar lavage on this basisand was followed up for two months after discharge.Body temperature recovery time,cough disappearance time,and hospitalization time after admission were compared between the two groups.Changes in inflammatory factors before treatment,one week after treatment,and two months after discharge were compared between the two groups.At the same time,the absorption area of the lung shadow one week after treatment was compared between the two groups.The incidence of adverse reactions during treatment was observed in both groups.Results:The temperature recovery time,cough disappearance time,and hospitalization time were significantly shorter in the treatment group than in the control group(P＜0.05).There were no statistically significant differences in serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8)levels between the two groups before treatment(P＞0.05).After one week of treatment,the serum levels of CRP,TNF-α,IL-6,and IL-8 in both groups decreased compared to those before treatment,and the treatment group was significantly lower than the control group(P＜0.05).Two months after discharge,the average levels of CRP,TNF-α,IL-6,and IL-8 in both groups decreased,but there was no statistically significant difference between the two groups(P＞0.05).At one week of treatment,the lung shadow absorption area of the treatment group was significantly larger than that of the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of children during treatment(P＞0.05).Conclusions:The application of bronchoalveolar lavage in early intervention of SMPP in children can effectively alleviate clinical symptoms,shorten the course of the disease,accelerate the relief of the inflammatory response,promote the absorption of lung shadows,and have good safety.
severe mycoplasma pneumoniabronchoalveolar lavageC-reactive proteinlung shadow absorption area
万方数据
维普
