The relationship between blood clozapine concentration and laboratory test indexes in patients with mental disorders
Objective:To investigate the relationship between blood clozapine concentration and laboratory test in-dices in patients with mental disorders.Methods:A total of 180 patients with mental disorders who were admitted to our hos-pital between June 2021 and June 2023 were selected,all of whom received the same dose of clozapine.Blood concentrations of clozapine and related laboratory indices,including high-density lipoprotein(HDL),aspartate aminotransferase(AST),total bilirubin(TBIL),creatine kinase(CK),creatine kinase isoenzyme(CKMB),glutamate aminotransferase(ALT),glutamyl transpeptidase(GGT),low-density lipoprotein(LDL),lactate dehydrogenase(LDH),direct bilirubin(DBIL),triglyceride(TC),and total cholesterol(TG),were measured after medication.In addition,the relationship between the blood concentration of clozapine and various laboratory indices was analyzed.Results:LDL and TG levels in the high concentration group were higher than those in the normal and low concentration groups,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in LDL and TG levels between the normal and low-concentration groups(P＞0.05).There were no statistically significant differences in HDL,AST,TBIL,CK,CKMB,ALT,GGT,LDH,DBIL,and TC levels a-mong the three groups(P＞0.05).Pearson's correlation analysis showed that LDL,TG,and clozapine blood concentrations were positively correlated(r＞0,P＜0.05).Conclusions:There is a close relationship between LDL and TG indicators and blood drug concentrations in patients with mental disorders treated with clozapine.When the levels of these indicators are abnormally ele-vated,the blood drug concentration should be detected as a reference indicator for adjusting pharmacokinetic parameters.
万方数据
维普
