Comparison of clinical efficacy and safety of atorvastatin calcium in different doses in the treatment of elderly patients with coronary heart disease
Objective:To investigate the effects of intensive and sequential doses of atorvastatin calcium in elderly patients with coronary heart disease.Methods:Eighty elderly patients with coronary heart disease admitted to the Dexing Hospital of Traditional Chinese Medicine from January 2021 to November 2022 were selected as study subjects and divided into two groups according to the random number table method.The control group(40 patients)was treated with an intensive dose of atorvastatin calcium(40 mg/time)once daily for 12 months.The observation group(40 cases)was treated with atorvastatin calcium in sequential doses;the initial dose was 40 mg/time,once a day for one month,and then the dose was reduced to 20 mg/time,once a day for 12 months.The cardiac function,serological indices,inflammatory reaction,quality of life,major cardiac adverse events,and incidence of adverse reactions were compared between the two groups.Results:Before treatment,there were no statistically significant differences in stroke volume(SV),cardiac output(CO),left ventricular ejection fraction(LVEF),high-density lipoprotein cholesterol(HDL-C),left ventricular end-diastolic diameter(LVEDD),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),alanine aminotransferase(ALT),aspartate aminotransferase(AST),C-reactive protein(CRP),tumor necrosis factor alpha(TNF-α),or various quality of life assessment questionnaire(GQOLI-74)indicators between the two groups(P＞0.05).After treatment,SV,CO,LVEF,HDL-C,and various GQOLI-74 indicators in both groups increased compared to those before treatment,and the observation group was higher than the control group.LVEDD,LDL-C,TG,ALT,AST,CRP,and TNF-α levels in both groups decreased compared to those before treatment,and the observation group was lower than the control group,with statistical differences(P＜0.05).There was no statistically significant difference in the incidence of major adverse cardiac events between the two groups(P＞0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion:Sequential dose atorvastatin calcium therapy is more effective in elderly patients with coronary heart disease,promoting the improvement of serum indicators in the body,reducing inflammatory reactions,improving heart function,reducing adverse reactions,and improving the quality of life.
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维普
