Clinical observation of metoprolol combined with trimetazidine in the treatment of dilated cardiomyopathy and heart failure
Objective:To observe the effect of metoprolol combined with trimetazidine in the treatment of heart failure in dilated cardiomyopathy.Methods:Eighty patients with heart failure and dilated cardiomyopathy treated in our hospital from January 2021 to December 2022 were selected and divided into an observation group(40 patients)and a control group(40 patients)using the random number table method.Both groups received conventional treatment according to the guidelines and simultaneously received trimetazidine orally,20 mg/time,three times a day.The control group was treated with a small dose of metoprolol(≤100 mg/day),and the observation group was treated with a large dose of metoprolol(150 mg/day).The treatment lasted for six months.Changes in cardiac function,inflammatory,and ventricular remodeling indicators before and after treatment were compared between the two groups.Results:Before treatment,there was no statistical difference in the left ventricular ejection fraction,left ventricular end-diastolic diameter,or left ventricular end-systolic diameter between the two groups of patients(P＞0.05).After treatment,the left ventricular ejection fraction of both groups of patients increased compared to that before treatment,and the left ventricular end-diastolic diameter and left ventricular end-systolic diameter decreased compared to those before treatment(P＜0.05).After treatment,the left ventricular ejection fraction of the observation group was higher than that of the control group,and the left ventricular end-diastolic and left ventricular end-systolic diameters were lower than those of the control group(P＜0.05).Before treatment,there was no statistical difference in the C-reactive protein(hs-CRP),interleukin-6(IL-6),angiotensin Ⅱ(AngⅡ),and transforming growth factor β1(TGF-β1)levels between the two groups of patients(P＞0.05).After treatment,the levels of hs-CRP,IL-6,AngⅡ,and TGF-β1 in both groups of patients were lower than those before treatment(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).Conclusion:A large dose of metoprolol(150 mg/day)combined with trimetazidine has a better improvement effect on cardiac function in patients with heart failure in dilated cardiomyopathy than a small dose of metoprolol(≤100 mg/day)and can inhibit the inflammatory reaction and ventricular remodeling.
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维普
