Clinical study of sodium valproate combined with clozapine in treatment of patients with refractory schizophrenia
Objective:To analyze the efficacy of sodium valproate combined with clozapine in the treatment of refractory schizophrenia(TRS).Methods:Sixty total with 60 TRS patients admitted to the our hospital between January 2020 and June 2023 were selected and divided into two groups according to the random number table method,with 30 cases in each group.The control group was orally administered clozapine(The initial dosage was 25 mg/time,3 times/day.After one week,the dosage was gradually increased to 200～300 mg/day for continuous three months).The observation group was treated with sodium valproate(in addition to the control group,the control group received oral sodium valproate at a dose of 250 mg twice a day for three consecutive months).Therapeutic effects in the two groups were compared.Results:The total effective rate in the observation group was significantly higher than that in the control group(P＜0.05).Before treatment,there was no significant difference(P＞0.05)in the scores of various dimensions within the Positive and Negative Symptom Scale(PANSS),Repeatable Set of Neuropsychiatric State Test(RBANS)scores,and polysomnography(PSG)monitoring between the two groups.After treatment,the PANSS scores of various dimensions in the observation group were lower than those in the control group.The SE and RBANS scores after treatment were higher than those in the control group,with TST,REM time,and S2 time longer than those in the control group,and awakening time and S1 time shorter than those in the control group(P＜0.05).There were no statistically significant differences in adverse reactions between the two groups(P＞0.05).Conclusion:Sodium valproate combined with clozapine alleviated psychiatric symptoms,restored cognitive function,improved sleep quality,and did not increase adverse reactions in TRS patients.
万方数据
维普
