Research progress on new technologies to improve bioavailability of Panax notoginseng saponins
Panax notoginseng saponins(PNS)are dammarane-type triterpenoid saponins extracted from the root of panax notoginseng,which have been used as natural medicines for many years because of their diverse pharmacological activities and medicinal values.However,the therapeutic potential of PNS is largely limited by their low bioavailability,mainly due to their high polarity,poor membrane permeability,instability in the gastrointestinal tract,and extensive metabolism in the body.This article reviewed the pharmacological effects,absorption and metabolic characteristics of PNS,the key factors affecting their bioavailability,effective strategies to improve their bioavailability,in order to deepen the understanding of PNS in different areas such as clinical treatment and disease prevention,to design a more efficient drug delivery system and maximize the therapeutic potential of PNS.
Panax notoginseng saponinabsorption and metabolism in the bodynew technologies for formulationsbioavailability
国家科技期刊平台
NSTL
万方数据
维普
