Optimization of the extraction process for Chinese herbal compound Biannaitong based on Box-Behnken response surface design
[Objective]To optimize the extraction process of Chinese medicine compound Biannaitong(BNT)by Box-Behnken response surface design.[Methods]Based on the single factor test,the influencing factors and range of BNT extraction process were optimized.The three-factor and three-level test design scheme was constructed by Box-Behnken response surface design method.The content of sennoside B,sennoside A and hesperidin was used as the response index to optimize the best extraction process conditions,and the process verification was carried out.[Results]The optimum extraction conditions of Chinese herbal compound BNT were as follows:solid-liquid ratio of 1∶8,reflux time of 30 min,extracting for 2 times.[Conclusion]The Box-Behnken response surface design method was used to optimize the BNT extraction process of traditional Chinese medicine compound.The method is stable and can provide a reference for the BNT extraction process.
国家科技期刊平台
NSTL
万方数据
