Effect and study on related mechanisms of Shenqi Fuzheng Decoction in treatment of hashimoto's thyroiditis combined with hypothyroidism
[Objective]To explore the clinical efficacy of Shenqi Fuzheng Decoction in the treatment of hashimoto's thyroiditis(HT)with hypothyroidism,and to analyze its therapeutic mechanism preliminarily.[Methods]The 110 HT patients admitted to our hospital from January,2020 to January,2023 were randomly divided into an observation group and a control group,with 55 cases in each group.Both groups were orally treated with levothyroxine sodium tablets.The control group were orally treated with sodium selenite tablets,while the observation group were treated with traditional Chinese medicine(TCM)Shenqi Fuzheng Decoction orally for 12 weeks.The TCM syndrome scores,thyroid volume and isthmus thickness,free triiodothyronine(FT3),free thyroxine(FT4),thyrotropin(TSH),thyroid globulin antibody(TGAb),thyroid peroxidase antibody(TPOAb),lncRNA MEG3,miR-17,Th17,Treg content,Th 17/Treg value before and after treatment were compared between the two groups,and the total effective rate was compared between the two groups.[Results]The TCM syndrome score of the observation group was lower than that of the control group(P＜0.05),and the thyroid volume and isthmus thickness were lower than those of the control group(P＜0.05).The serum levels of FT3,FT4 were higher than those of the control group(P＜0.05).TSH,TGAb,and TPO Ab were lower than those in the control group(P＜0.05).The Th 17,Th 17/Treg,and miR-17 levels of the observation group were lower than those of the control group(P＜0.05),while Treg and lncRNA MEG3 levels were higher than those of the control group(P＜0.05).The total effective rate of treatment was higher than that of the control group(P＜0.05).[Conclusion]Shenqi Fuzheng Decoction can effectively improve traditional Chinese medicine syndromes and thyroid function,regulate thyroid autoantibodies,reduce thyroid volume,and it has a significant therapeutic effect on HT combined with hypothyroidism.Its mechanism may be related to the regulation of serum lncRNA MEG3 and miR-17.
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