The mechanism of Xuanfei Baidu Granules to treat influenza virus pneumonia by increasing T cells
[Objective]To establish a influenza virus(A/PR/8/34)pneumonia model under low temperature and high humidity,and evaluate the efficacy and mechanism of Xuanfei Baidu Granules(XFBD)against influenza.[Methods]ICR mice were placed in an artificial climate box with low temperature and high humidity,and influenza virus(A/PR/8/34)was given intranasally.On the 5th day after modeling,mice were given XFBD by gavage for 5 d.The behavioral score,body weight,organ index,pulmonary viral load,pulmonary imaging and morphological changes were observed and recorded.The expression of NF-κB,a key inflammatory protein,was detected by Western blot,and the regulation of XFBD on the immune response of mice was detected by flow cytometry.[Results]Compared with the model group,after administration of XFBD,mice showed increased activity,normal stool characteristics,decreased lung viral load,decreased inflammatory exudation in mice's lungs,decreased expression of p-NF-κB P65,and increased percentages of CD4+and CD8+T cells.[Conclusion]XFBD increased the amount of T cells,and inhibited the inflammation of the influenza virus pneumonia under cold and high humidity conditions.
万方数据
维普
