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绵萆薢化学成分的分离与结构鉴定

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[目的]#对绵萆薢的化学成分进行研究。[方法]采用大孔吸附树脂、ODS、Sephadex LH-20等柱色谱及制备型高效液相色谱法对其所含化学成分进行分离、制备,并利用波谱学方法鉴定了结构。[结果]从绵萆薢提取物中分离鉴定了Tachioside(1)、Isotachioside(2)、3,5-二甲氧基熊果苷(3)、2,6-二甲氧基-4-羟基-苯酚-1-O-β-D-吡喃葡萄糖苷(4)、淫羊藿次苷D2(5)、苯甲醇-O-β-D-吡喃葡萄糖苷(6)和腺苷(7)等7个单体成分。[结论]化合物1~3为首次从薯蓣属中分离得到,4~7为首次从该植物中分离得到。
Isolation and structural identification of constituents from Dioscoreae spongiosae Rhizoma
Objective] Study on chemical constituents of Dioscoreae spongiosae Rhizoma. [Methods] The chemical constituents were obtained by ODS, Sephadex LH-20 and PHPLC chromatorgraphy isolation, and identified by chemical and spectral analysis. [Results] The structures of seven comounds were elucidated to be tachioside (1), isotachioside (2), koaburaside (3), 2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (4), icariside D2 ( 5 ) , benzyl alcohol O-β-D-glucopyranoside ( 6 ) , and adenosine ( 7 ) , respectively . [ Conclusion ] Compounds 1~3 were obtained from Dioscoreae genus firstly, and 4~7 was isolated from the plant for the first time.

Dioscoreae spongiosae Rhizomachemical constituentsstructural identification

晁利平、阮静雅、刘艳霞、韩立峰、王涛、张祎

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天津市中药化学与分析重点实验室,天津 300193

绵萆薢 化学成分 结构鉴定

新世纪优秀人才支持计划资助项目天津市高等学校创新团队培养计划资助项目

NCET-12-1069TD12-5033

2016

天津中医药大学学报
天津中医药大学

天津中医药大学学报

CSTPCD
影响因子:1.324
ISSN:1673-9043
年,卷(期):2016.35(5)
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