Clinical observation of auricular vagus nerve electrical stimulation in the treatment of negative emotions in patients with polycystic ovary syndrome
[Objective]To observe the effect of auricular vagus nerve electrical stimulation on negative emotion in patients with polycystic ovary syndrome(PCOS).[Methods]The 60 patients with PCOS were randomly divided into electrical stimulation group and control group,with 30 patients in each group.Both groups received lifestyle intervention on the 5th day of menstruation,and the electrical stimulation group was combined with auricular vagus nerve electrical stimulation.Both groups were treated for 1 month as a course of treatment,with a total of 3 treatments.The scores of self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS),as well as traditional Chinese medicine(TCM)medicine symptom score,body mass index(BMI),glucose metabolism index(FINS)and fasting blood glucose(FBG),homeostasis model insulin resistance index(HOMA-IR)and levels of inflammatory factors[serum interleukin 1(IL-1),interleukin 6(IL-6)and tumor necrosis factor α(TNF-α)]before and after treatment were compared between the two groups.[Results]Compared with before treatment,the scores of SAS and SDS,TCM symptom scores,FINS,FBG and HOMA-IR,serum levels of IL-1,IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05).In the control group,the scores of TCM symptoms and FINS,FBG and HOMA-IR were decreased(P<0.05).Compared with the control group,the scores of SAS and SDS,TCM symptom scores,FINS,FBG and HOMA-IR,serum levels of IL-1,IL-6 and TNF-α were decreased in the electrical stimulation group after treatment(P<0.05).[Conclusion]The application of auricular vagus nerve electrical stimulation in the treatment of PCOS patients can effectively improve the anxiety and depression,improve blood glucose metabolism and reduce inflammation.
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