Research progress on the role of microRNA-124 in Alzheimer's disease and acupuncture intervention
Alzheimer's disease(AD)is a common neurodegenerative disease of the elderly.The etiology of AD is now mostly thought to be related to abnormal deposition of Aβ in the brain,hyperphosphorylation of the related protein Tau,and release of various cytokines and complement.microRNA-124 is highly expressed in the central nervous system and is associated with many neurophysiological and pathological processes.microRNA-124 functions in AD in a variety of ways through Aβ deposition,Tau protein hyperphosphorylation,neuroinflammation,oxidative stress,neuronal excitability,and neural differentiation.It may also adversely affect synaptic plasticity and axonal growth by regulating apoptosis,which in turn affects AD.Therefore,it is crucial to explore the changes in microRNA-124 expression in AD and targeting therapy.The clear efficacy of acupuncture in treating AD may be related to microRNA-124 modulation.In this paper,we review the relevance of microRNA-124 to several typical histopathological features possessed by AD,including Aβ accumulation in age spots,Tau hyperphosphorylation,neuroinflammation,and synaptic loss.The role of microRNA-124 in AD through targeting different genes as well as regulating downstream signaling and the possible intervention mechanisms of acupuncture for AD are reviewed to provide new ideas for future treatment.
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