Progress in the study of the anti-hepatocellular carcinoma effect of glycyrrhizin acid/glycyrrhetinic acid
Liver cancer is the second most difficult lethal disease in treatment in the world which belongs to refractory malignant tumors.Chemotherapy is responsible for anti-cancer treatment.Until now,most drugs of anti-cancer are hydrophobic molecules with lower relative molecular mass and commonly lack drug specificity for tumor cells.Meanwhile,some issues about the drugs like low bioavailability,serious toxic side effects,and the difficulty of passing through cell membranes and other natural physiological barriers greatly limit the therapeutic effect of drugs in clinical practice.Glycyrrhizin is an active ingredient extracted from the dried roots and rhizomes of traditional Chinese medicine(TCM)licorice.It is also a natural surfactant with an amphiphilic structure,and glycyrrhetinic acid is its main hydrolysate.It's demonstrated that glycyrrhizin/glycyrrhetinic acid can specifically target the liver and have multiple anti-tumor activities.Heretofore glycyrrhizin/glycyrrhetinic acid has been applied in various anti-tumor nanocarrier systems such as"shell-core"drug delivery micelles,liposomes,and nanoparticles.The drug delivery decorated by glycyrrhizin/glycyrrhetinic acid makes targeting liver therapy reliable,it can improve the bioavailability of anti-liver cancer drugs and reduce their toxic side effects on the human body,while also exerting their synergistic anti-tumor effects,ultimately achieving the goal of enhancing the anti-liver cancer efficacy of the anti-cancer drug system.In this article,glycyrrhizin/glycyrrhetinic acid is discussed to research progress on the application of anti-liver cancer drug delivery systems and anti-liver cancer pharmacological effects,this overview provides reference regarding a better understanding of the development of liver-targeted anti-cancer drug system.
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